Native Cellular Fluorescence of Thyroid Nodules
Principal Investigator: Howard Savage, Ph.D.
Objective: To identify the spectral signature of thyroid cancer so as to facilitate cancer screening without the need for invasive biopsies
Overview: This project utilizes tumor DNA to perform a comparative analysis of cancer to normal tissue. Following polymerase chain reaction amplification of tumor DNA, cancers are assessed for the loss or gain of chromosomal regions. The relationship of these alterations to clinical characteristics of the patient are assessed. Departmental Co-Investigators are Stimson Schantz, MD and Michael Pittman, MD.Contact
Information: Howard Savage, Ph.D., (212)
979-4200
Funding: American Academy of Otolaryngology - Michael Pittman, MD
Selected Publications & Presentations:
Katz A, Savage HE, Schantz
SP, McCormick SA, Alfano RR. Noninvasive native fluorescence imaging of
head and neck tumors. Technology in Cancer Research and Treatment
2002; 1:9-7. [Abstract]
Gayen SK, Alrubaiee M, Savage H, Schantz SP, Alfano RR. Parotid gland
tissues investigated by picosecond time-gat ed and optical spectroscopic
imaging techniques. IEEE Journal on Selected Topics in Quantum
Electronics 2001; 7:906-911. [Abstract]
Guo Y, Savage HE, Liu F, Schantz SP, Ho PP, Alfano RR. Subsurface
structure of tissues investigated by noninvasive optical second harmonic
tomography. Proceedings National Academy of Sciences USA 1999;
96:10854-10856. [Abstract]
Schantz SP, Kolli VK, Savage HE, Yu G, Shah JP, Harris DE, Katz A,
Alfano RR. Huvos AG. In-vivo native cellular fluorescence and histologic
characteristics of head and neck cancer. Clinical Cancer Research
1998; 4:1177-1182. [Abstract]
Related Information: Other Research Projects in Head and Neck Oncology
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